Hemoglobin A1c to Become a Preferred Test for Diagnosing Diabetes

More than 8% of the US population, which means about 24 million people in this country are diabetic. The prevalence of diabetes is increasing and the number of diagnosed cases of diabetes is expected to reach 35 million by the year 2030.

The American Diabetes Association (ADA) along with the European Association for the Study of Diabetes and the International Diabetes Federation, is strongly considering recommendation of using the Hemoglobin A1c (HbA1c) test as a preferred test for diagnosing diabetes. Many physicians have already been using this test either as an alternative screening tool to diagnose diabetes or as an additional confirmation test for diagnosis. The conventional practice has, so far, used fasting plasma glucose and oral glucose tests to diagnose diabetes, but patients and their doctors do not find these tests very user friendly. Back in the year 2003, the International Expert Committee, including ADA did not recommend using the HbA1c as a screening tool to diagnose diabetes, because different clinical laboratories produced variable results and did not have standardized methods of measurement of HbA1c. However, initiatives by National Glycohemoglobin Standardization Program (NGSP) have improved consistency in the measurement of HbA1c by different laboratories. This move has made the experts to re-consider using the HbA1c test as a diabetes screening and diagnosing tool.

According to many experts, including Christopher Saudek, MD, professor of medicine at Johns Hopkins University School of Medicine in Baltimore, this is an easy to use test, which will be able to help diagnose more patients with diabetes, much earlier in the course of the disease. At this time, unfortunately, almost 40% of the cases remain undiagnosed, and one major reason for this is that the test in practice requires overnight fasting, and many patients either do not like fasting or they just forget to fast before the test. Testing of HbA1c does not require patients to fast, and thus, is perceived as easy and convenient.

The experts at the ADA have recommended that the HbA1c of 6.5%, confirmed by plasma glucose-specific test, should be used as a test to diagnose diabetes. The committee has also recommended further follow-up and more testing, when the HbA1c of a patient is tested at 6.0% or more. Some argument is provided by other experts like Davidson and colleagues (Buell C et al. Diabetes care. 2007; 30(9):2233-2235), about the acceptable HbA1c cutoff point for diagnosing diabetes. They believe that people with HbA1c of 6.0% or less should be considered normal, those with a value of 6.1% to 6.9%as pre-diabetics and a value of 7.0% or higher should indicate diabetes.

It is important for us to know that people with any of the following risk factors- obesity, high blood pressure/ hypertension or a family history of diabetes should get tested for their HbA1c, at least twice a year. Using HbA1c test as a screening tool, will help detect diabetes in more people, especially who are at risk and who would otherwise be left undiagnosed. This will help physicians and their patients intervene early and help them formulate optimal treatment strategies.

Testing of HbA1c is now even more easy and simple through dried bloodspot testing introduced by ZRT laboratory. The patients can perform this test at the convenience of their home, without going to a phlebotomist to get their blood drawn. For more details about dried bloodspot testing, visit ZRT website www.zrtlab.com or feel free to email me at skapur@zrtlab.com.

Healthy Looking but Still High Blood Pressure?

I recieved an email from a mom who shared with me few details about her 16 year old, healthy looking son's high blood pressure problems. She is very concerned about her son's future health risks associated with hypertension and is looking for some answers. I did respond to her email below, but I would appreciate comments from my readers and if any one has any suggestions in this case.

Mom: Dr. Kapur, My son, who is 16 years old, has been running a “borderline” blood pressure. He had an athletic physical last year and this year where the nurses repeated his pressures multiple times. He is 6’2” and 172 pounds. He plays basketball and soccer. He does not like, thus does not drink any type of soda pop...but he does drink gatorade type of drinks as well as lots of water. He is diet is good, but not great. We rarely eat fast food. I do grow my own garden and can/freeze food. BUT, being busy with an athletic schedule, he does occasionally eat food that is not healthy.
Family history includes a grandmother that died about 2 years ago at the age of 58 due to an apparent heart attack. She did have issues with hypertension. She was 5' 8" and 220 pounds. She was extremely active/busy. BUT she did have a lot of stress....mother of 12 children, drove school bus, and owned a restaraunt. She was asymptomatic expect for the hypertension that was being treated by 3 antihypertensive agents....Catapress Patch, Tenormin, and Hydrochlorothiazide. She had a similar diet to my son....probably better. Her activity did not include a regular exercise plan or a cardio plan....my son has a vigorous exercise plan as he continuously plays basketball and soccer. She was overweight....my son does not have any extra weight on his body.

What can be done to improve my son's blood pressure??? He is passing his physicals now, but I am concern that with time he will need medication to maintain a normal blood pressure. AND the diastolic number is more of the issue than the systolic. Nothing has been done at this point. If I do a cardioprofile, will you be able to guide me if his numbers are out of range???? Is it genetic? Or is there a mineral or nutrient lacking in his diet that is the factor. My mother and my son have always lived in the same town. We do live in a rural farming community. My parents farmed organically, but neighbors do not farm in the same way...thus I understand that the air, water, etc is contaminated.

My Response: Thank you for sharing this information about your son. His BMI (Body Mass Index) is 22.08. This BMI puts him under the body classification of “Average” type. So, for him losing weight should not be the focus for controlling the blood pressure, however he still should keep healthy lifestyle to stay fit. This is good that he does not drink any type of soda pop; at the same time drinking Gatorade type of drinks may not be recommended for people with borderline or high blood pressure because of their high sodium content. Sodium in Gatorade is about 450 mg per liter. According to FDA the sodium content should not exceed 360 mg per serving for individual foods and about 480 mg per full serving for full meal. For individuals at risk, these limits are even lower, so it is good to consume less of any such drink types with high sodium content.

The American Heart Association recommends that people with high blood pressure should eat foods with low-sodium, low-fat, and low-cholesterol. So read food labels and check for any names with “sodium” like sodium hydroxide, sodium benzoate, monosodium glutamate or disodium phosphate etc. You mentioned that you grow your own garden. This is excellent because consumption of processed foods should be minimal as those are usually high in sodium. Any type of canned or pre-packaged frozen food should be avoided. Herbs and spices like garlic and onion, basil, parsley, thyme, black pepper, turmeric, etc are should be used for cooking.

Few researchers have been able to identify some abnormalities in a gene that have been linked with hypertension and therefore, there may be some increased likelihood of problems related to high blood pressure in individuals with variations in this gene. It is difficult at this time to clearly identify the genetic cause of high blood pressure because it is the interaction of inherited mutations/ genes with other genes and the environment that we all live in. A test is available to detect such type of inherited genetic variations that encode for a protein called G-protein coupled receptor kinase type 4 (GRK4). An individual carrying this variation is more prone to conditions like hypertension. This type of genetic variation is linked with inability to eliminate sodium from the body. So, even without going for this type of genetic testing, limiting sodium consumption should help control blood pressure in healthy looking individuals like your son. Other than that, foods rich in potassium are good. Foods like soya, wheat bran, tomato, raisins, unsalted nuts, potatoes, spinach, zucchini, bananas, melons, oranges, and figs etc. have high potassium content. Potassium and sodium work together to control blood pressure. Honey and fish oils have also shown to regulate blood pressure in normotensive individuals.

Your son is 16 and very young and so I am sure alcohol consumption is not an issue in his case. Drinking alcohol also raises blood pressure in otherwise healthy looking people. Hypertensive patients should always stay away from alcohol.

Please look at the link below for few important ADA guidelines on regulating blood pressure.
http://www.guideline.gov/summary/summary.aspx?doc_id=12817&nbr=6619&ss=6&xl=999

First Michael Jackson and Now Billy Mays- Is There Something In Common?

First Michael Jackson and now Billy Mays, both died at a young age of 50 and both of them likely due to heart disease. Is this just coincidence or is there something common. Should we worry about the number 50?

Does the word “Stress and hypertension” ring the bell when you think of celebrities?

Billy Mays was in an airline accident a day before. Someone said ,”He survived the accident but probably this stressed the hell out of his heart which just never caught up…”. This is not just one time stress though; this is not because of a single event that one gets a heart attack. Heart disease develops overtime and several factors could contribute to this problem. “Mays suffered from hypertensive heart disease, and the wall of the left ventricle of May’s heart and the wall of one of his arteries were enlarged” said Vernard Adams, Hillsborough County Medical Examiner. So, is this hypertension that killed Billy Mays? Well, it is likely that he died of heart attack in his sleep, but it might take few more weeks to perform several tests to determine the exact cause of his death.

Although, a direct relationship between stress and hypertension is still unclear but stress can indirectly cause hypertension through repeated blood pressure increases and also by affecting the nervous system to produce hormones that raise blood pressure. Could an airline accident have caused sudden elevations in Mays’ blood pressure damaging his heart?

Hypertension is one of the most significant contributor to heart disease and stroke. Unfortunately one third of those who suffer from hypertension are unaware of their condition as it is asymptomatic. As a result, almost two thirds of those remain untreated or undertreated.
High blood pressure does not cause any symptoms, at least in its early stages and so it becomes very important to monitor your blood pressure regularly, once every year, if you think you are normal and have no risk conditions or disease. High blood pressure causes weakening of the arteries, which makes them more susceptible to damage and plaque build-up around their walls. This results in a condition called atherosclerosis.

What is considered to be normal blood pressure? Less than 120/80 mmHg is normal. What is Pre-hypertension? When the blood pressure is between 120/80 and 140/90, it is known as moderately high and the individual is pre-hypertensive. Finally, what is hypertensive? Blood pressure of 140/90 or higher (130/80 for diabetics) is called hypertension. So, the goals of therapy should be to lower the blood pressure to less than 140/90 for those without diabetes and to less than 130/90 for those with diabetes.

Regular blood pressure checks is the first step to lowering the blood pressure in order to avoid heart problems. Antihypertensive medications are helpful but even among those using such medicines, only about 53% have their blood pressure under control. American Diabetes Association has recommended that just a 12- to 13-point reduction in blood pressure by positive lifestyle changes can reduce risk of myocardial infarction by 21%, stroke by 37% and all death from cardiovascular disease by 25%.

Positive lifestyle modifications remain the cornerstone of controlling and managing blood pressure/ hypertension, which include 1) weight loss, 2) regular aerobic activity with at least one 40-minute moderate intensity exercise every week, 3) diet rich in fruits, vegetables, potassium and calcium, 4) reduced salt intake, and 5) moderate alcohol consumption. These changes are extremely helpful in controlling the blood pressure and also blood glucose and lipid levels, thereby helping in prevention of cardiovascular disease.

Hypertension is not just a problem of adults, but children should also be monitored for high blood pressure. Children also develop hypertension due to same reasons as adults- unhealthy diet, not being active and accumulating some extra pounds. When diagnosed with high blood pressure, children should be treated with making healthy lifestyle changes aimed at weight control and increased physical activity. In some cases, pharmacologic intervention may be required.
Although age does increase your risk of getting a heart disease and you cannot do much about this, but you can definitely control other risk factors that multiply the overall risk.

Of course, heart disease has nothing to do with the number 50 and all those in their 50’s or turning 50 should not be alarmed. Celebrate your 50th year and celebrate the lives and legacies of Michael Jackson and Billy Mays, and remember it is never too late to make healthy and positive lifestyle changes.

If It can Happen to Michael Jackson, It Can Happen to Anyone…

The world is in shock and mourning Michael Jackson’s sudden death reportedly due to cardiac arrest. As people are posting tributes to him everywhere, he is being remembered as “The King of Pop”, “Icon”, “Legend”, but there is one thing that we all need to remember is that he was human just like all of us.

Michael’s unexpected passing away at just 50 leaves behind a good lesson for us. We need to stop and think seriously. Yes, this is a catastrophic tragedy, and all of us are perplexed thinking how could someone like Michael, who was not obese, had a thin stature, physically active as a dancer, very athletic die of cardiac arrest. It is not very uncommon for healthy looking people to have heart disease; and cardiac arrest is the first sign of heart disease.

Someone asked me a question this morning “Dr. Kapur, given that the initial explanation of the sudden death of Michael Jackson was cardiac arrest - can you explain the relevance or relationship of that event to Cardiometabolic Syndrome?”

Cardiac arrest occurs when there is disruption of electrical signals in heart muscles, which therefore prevents the heart from pumping blood effectively, causing a heart attack. There are more chances of getting a cardiac arrest when there has been previous heart damage due to a heart attack (blockage of arteries). This does not mean that someone who has not had any previous event cannot have a cardiac arrest. It has been reported by several studies that people with high cholesterol, high blood pressure and/or with family history of heart disease or diabetes are at risk of dying of heart disease even when they appear thin and healthy. Stress, smoking and drug abuse have been shown to have an added risk. So, even when we are athletic, thin looking with no family history of heart disease, we need to be aware of our cholesterol and triglycerides at all times.

“What steps should those who might be reflecting upon their own ‘heart health’ take to insure that they are being smart about preventative steps?”

Healthy eating, active lifestyle and monitor your health regularly without waiting for your doctor to tell you what to do is the key. Check cholesterol levels and In addition to cholesterol levels, it is important to check glucose and inflammatory markers like C-reactive protein, which is emerging as an independent risk factor for heart disease. It is recommended that people care for their own health and wellness by monitoring their cardiometabolic markers like cholesterols, triglycerides, hemoglobin A1c and C-reactive protein and not wait for their doctor to suggest these tests. This is because even doctors will not suggest these tests until they see any symptoms; so why wait until any symptoms appear. Heart disease and diabetes are like an iceberg that is hundred times larger than what is seen on top. These diseases start way before the actual symptoms appear. It is smart to be proactive and take steps to prevent such diseases.

As we all say “Adieu” to Michael, let us learn a lesson that he leaves behind for us…

What is Cardiometabolic Risk?

Soft Drinks, Fruit Drinks, Energy Drinks and Cardiometabolic Risk

It really depends upon how much we like soft drinks, fruit drinks, energy drinks or any other type of sweetened caloric beverages before we can make a choice between our cravings and our cardiometabolic risk. Scientific research has shown a number of times in the past how much we have to be watchful of our caloric consumption, not just from the food we consume but also from the beverages we enjoy. Nurses’ Health Study has shown about 49% increase in the risk of coronary heart disease in women due to regular soft drink consumption. Nurses’ Health Study II has also shown a direct link between sweetened drinks and increased risk of diabetes, irrespective of total body weight. Framingham study has suggested a strong association between metabolic syndrome and soft drink intake. Another recent research study reported about 44% increased chances of getting diagnosed with metabolic syndrome if someone consumed one soft drink every day as compared to those who did not drink such sweetened caloric beverages frequently.

Unfortunately, there is a rising trend in the consumption of flavored and sweetened energy drinks, fruit drinks, vitamin water especially in United States and the intake of these beverages has tripled in last few years, which is now emerging as a major cause of obesity in children and also conditions like weight gain, insulin resistance and other cardiovascular risk factors in adults.

We have definitely seen some direct or indirect effects of the sweetened caloric drinks on our overall health and wellness. Several articles have been published in this direction, both scientific and in lay press; many research studies have identified statistically significant associations between soft drink consumption and increased body weight, diabetes and heart disease. There is no doubt about adverse and unhealthy effects of most of the sugar and fizzy drinks and I think there is no need for us to wait for further evidence to prove it again. It is time to do something about correcting the mistakes we have made so far.

All along we have been saying “We are what we eat”, but now it is all about “We are what we eat…and drink”. It is not very difficult to watch what we choose to drink when we think of healthy weight loss or just when we are thirsty. I remember my grandma sharing with me benefits of drinking water, green tea, pomegranate juice for several health reasons she could outline (all appearing non-scientific at the time) as she never went to school, but now when I think of those, I feel she knew much more science than most of us scientific pundits of today.

What are we waiting for? What more proofs do we need before we do something about this problem? Why are we debating on this subject for so long? We are becoming aware of what we eat, but should we also not be concerned about what we are drinking or what we are making our children drink? Let us create a better “Healthy Tomorrow” for our generations to follow.

Let us stop and make some intelligent choices about “drinking healthy” and let us appeal to manufacturers to make healthy drinks free of any harmful effects. At the same time, let us practice and educate ourselves about picking up the right drinks in order to prevent and manage any chronic diseases like metabolic syndrome, diabetes, heart disease and other related conditions. Let us all work together.

I will be Speaking at the A4M Meeting in San Jose on September 9-12, 2009

I will be talking about "Simple Cardiometabolic Risk Screening using Bloodspot Technology" at the 17th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies on September 9-12, 2009 at the San Jose Convention Center in San Jose, CA.

The growing numbers of people with cardiovascular disease and diabetes in the United States is a consequence of metabolic disorders largely associated with obesity. As people age, the decline in hormone levels and the decrease in activity levels can combine to increase an individual’s tendency to visceral obesity, which sets up the metabolic conditions that lead to cardiovascular disease and diabetes and are referred to as cardiometabolic risk. Blood spot testing for cardiometabolic risk markers can reach a large number of people and help them control their risk by making lifestyle changes. This can significantly improve wellness in the aging population. A simple blood spot test can conveniently and accurately assess cardiometabolic risk, giving people the opportunity and motivation to control their risk with appropriate lifestyle changes. Broader screening in the aging population may be the key to reversing the growing incidence of cardiovascular disease.